Cambridge Isotope Laboratories Inc Archives

Cambridge Isotope Laboratories, Inc. and Chemtatva Chiral Solutions Pvt. Ltd. to Establish Cambridge Isotope Laboratories, Pvt. Ltd. in Hyderabad, India

Strategic Partnership to Establish Cambridge Isotope Laboratories, Pvt. Ltd. in Hyderabad’s Genome Valley, Enhancing Global Production and Supply of Isotopically Enriched Chemical Solutions for Pharmaceutical and Electronics Industries

Cambridge Isotope Laboratories, Inc. (CIL), and Chemtatva Chiral Solutions, Pvt. Ltd. (CCS), a leading provider of chiral and specialty chemical solutions, announce the execution of a signed Memorandum of Understanding to establish Cambridge Isotope Laboratories, Pvt. Ltd. in Hyderabad, India. This initiative marks a milestone in the expansion of CIL’s global footprint and further enhances capabilities in the development and production of deuterated reagents and other isotopically enriched products. This partnership will enhance global supply chain strength and real-time support for customers in Asia and enable multi-site production for global customers focused on business continuity. The forthcoming entity, Cambridge Isotope Laboratories, Pvt. Ltd., is expected to be officially established in Q4 2025, subject to customary diligence and closing considerations. Operations for the newly formed entity will be initiated at existing CCS facilities, with a net new facility slated for groundbreaking in 2026. The new facility will be located in India’s Genome Valley, a burgeoning 2,000-acre life sciences cluster located in suburban Hyderabad.

Cliff Caldwell, CEO at CIL noted, “We are excited to partner with CCS to combine our chemistry expertise and pursue scale-up technologies to further support pharmaceutical and industrial applications. This initiative reflects our commitment to supporting global research and development efforts in scientific fields as well as supporting the growing commercial needs for deuterium labeled and specialty chemical products in the pharmaceutical and electronics industries.”

Vishal Rajput, CEO of CCS said, “The collaboration and newly formed entity will leverage CCS’s strong infrastructure and deep technical capabilities in India, while integrating CIL’s world-class standards in isotope chemistry, quality systems, global logistics and go-to market capabilities.” Mr. Rajput will lead the newly formed entity as general manager of Cambridge Isotope Laboratories, Pvt. Ltd. The legacy CCS business will remain intact, with the collective intent to expand access to high quality, isotopically labeled and unlabeled compounds for customers worldwide, with an emphasis on downstream synthetic compounds and a commitment to industry-specific product quality requirements.

All CIL, Eurisotop and CCS branded and manufactured materials remain available to Indian and worldwide customers through existing channels. Further details regarding the launch and operational scope of Cambridge Isotope Labs Pvt. Ltd. will be shared in the coming months.

About Cambridge Isotope Laboratories, Inc.
CIL, a subsidiary of Otsuka Pharmaceutical in Japan, is the largest manufacturer and global supplier in the world of stable isotopes and stable isotope‑labeled compounds. Trusted by industrial and academic collaborators since 1980, CIL’s products are used in research, diagnostics, environmental, pharmaceutical, medical diagnostic, OLED, and industrial applications. CIL’s operations include two facilities in the Boston, MA, area; a large isotope‑enrichment production plant in Xenia, OH; CIL China; CIL Canada; ABX in Dresden, Germany (specializing in radioisotopic‑labeled compounds for cancer diagnosis and treatment); and Eurisotop in Saclay, France.

About Chemtatva Chiral Solutions, Pvt. Ltd.
CCS is a Hyderabad-based company founded in 2021, specializing in chiral chemistry, process development, and custom synthesis for pharmaceutical and chemical industries. CCS is a trusted global partner in life sciences, delivering innovative chemistry solutions that solve complex challenges and accelerate scientific progress.

Contact Information
Crissy Krisko
crissyk@isotope.com
1.978.269.1930

SOURCE: Cambridge Isotope Laboratories, Inc.

Cambridge Isotope Laboratories, Inc. Unveils ISOAPI-D – a New Standard in Deuterated Reagents for Pharmaceutical Innovation – at CPhI Frankfurt 2025

With ISOAPI-D, CIL offers pharmaceutical partners a secure, global supply of deuterated reagents – manufactured to the highest quality standards for faster, more efficient API development.

Cambridge Isotope Laboratories, Inc. (CIL), a global leader in stable isotope chemistry, announces the launch of ISOAPI-D™, a unified brand of deuterated intermediates for API synthesis. The new ISOAPI-D brand will be launched at CPhI Frankfurt, where CIL welcomes industry professionals to stand #2.0G2 from October 28-30.

ISOAPI-D
ISOAPI-D Power of Deuterium: Smarter, Stronger Therapeutics

“ISOAPI-D reagents are designed to support the development of next-generation active pharmaceutical ingredients (APIs) by leveraging the unique benefits of deuterium incorporation,” said Cliff Caldwell, CEO of CIL. “With ISOAPI-D, our customers gain access to a trusted and secure supply chain, ensuring they have consistent, reliable access to the materials they need for robust and efficient drug development.”

CIL’s global manufacturing network, including facilities in North America, Europe, and Asia, enables CIL to provide a diversified and resilient supply chain for pharmaceutical partners. Every ISOAPI-D product is manufactured in ISO 9001-certified facilities, ensuring the highest standards of quality, regulatory compliance, and full traceability throughout the production process.

A core component of the ISOAPI-D line is heavy water (D₂O), which is sourced exclusively from approved suppliers. This product is fully traceable and tritium-free, aligning with stringent safety and regulatory requirements of the pharmaceutical industry.

The ISOAPI-D range also features advanced intermediates that allow for more streamlined synthetic pathways. By reducing the number of synthesis steps and optimizing production efficiency, these intermediates can help lower manufacturing costs and accelerate the time to market for new therapeutics.

Since 1981, CIL has been a trusted supplier of premium deuterated materials to leading pharmaceutical and biotechnology companies worldwide. This longstanding commitment to quality and reliability continues with the launch of ISOAPI-D, offering customers a secure, high-quality supply of essential reagents and reducing operational risk in their development pipelines.

“ISOAPI-D represents the next step in our ongoing mission to support pharmaceutical innovation,” said Tasha Agreste, Business Development Manager Deuterated Reagent Applications, at CIL. “Our expanded manufacturing capabilities, rigorous quality standards, and decades of experience position CIL as a reliable partner for the industry’s evolving needs.”

Visit CIL at CPhI Frankfurt, Stand #2.0G2, October 28-30, to discover ISOAPI-D, the future of deuterated chemistry for pharmaceuticals.

Trusted by industrial and academic collaborators since 1980, CIL’s products are used in research, diagnostics, environmental, pharmaceutical, medical diagnostic, OLED, and industrial applications. CIL’s operations include two facilities in the Boston, MA, area; a large isotope‑enrichment production plant in Xenia, OH; CIL China; CIL Canada; ABX in Dresden, Germany (specializing in radioisotopic‑labeled compounds for cancer diagnosis and treatment); and Eurisotop in Saclay, France.

Contact Information
Crissy Krisko
crissyk@isotope.com
1.978.269.1930

SOURCE: Cambridge Isotope Laboratories, Inc.

CIL Announces Breakthrough in Benzene Recovery, Addressing Cost, Environmental, and Supply Challenges for OLED Display Manufacturers

Cambridge Isotope Laboratories, Inc. (CIL) has successfully developed and implemented a game-changing benzene-d6 recovery program, addressing major pain points for manufacturers of organic light-emitting diode (OLED) displays. This innovative service reduces costs, minimizes environmental impact, and conserves scarce deuterium supplies.

OLED display producers rely heavily on deuterated benzene (benzene-d6) as a critical starting material in their synthesis processes. However, this results in significant quantities of depleted benzene-d6, which is no longer usable but still retains considerable deuterium value. The disposal of such depleted material poses environmental challenges and substantial expenses.

CIL’s benzene-recovery program offers a transformative solution. Customers can now return their depleted benzene-d6 to CIL, where it undergoes a proprietary re-enrichment process to restore it to virgin material quality. This service is available at a significant cost savings compared to new benzene-d6, providing significant economic benefits.

Beyond the financial advantages, the program has far-reaching environmental and supply implications. It eliminates the need for costly disposal, reduces the demand on increasingly scarce deuterium (derived from heavy water, D2O) and conserves this vital resource for its growing applications in science, medical diagnostics, pharmaceuticals, and semiconductor production.

Recycling offers several sustainable benefits. It reduces pollution by releasing fewer chemicals into the environment. Recycling also saves energy, as reprocessing chemicals like benzene requires less energy than producing them from raw materials. This leads to lower greenhouse gas emissions, helping to combat climate change.

“This initiative underscores CIL’s commitment to collaboration and innovation in addressing our customers’ most pressing challenges,” said Cliff Caldwell, CEO of CIL. “By recovering and re-enriching depleted benzene-d6, we create a circular economy approach that is both economically and environmentally sustainable. As the world’s largest supplier of benzene-d6, we are uniquely positioned to deliver this groundbreaking service.”

CIL’s benzene recovery program is the result of 12 months of dedicated development, expansion, and rigorous testing to ensure reliable capacity and uncompromising quality. CIL invites interested parties to inquire about the program’s details and how to participate.

About Cambridge Isotope Laboratories, Inc.
CIL is the world’s largest manufacturer and global supplier of stable isotopes and stable isotope-labeled compounds used in research, environmental, pharmaceutical, medical diagnostic, OLED, and industrial markets. CIL subsidiary ABX, located in Dresden, Germany, is active in the development and commercialization of radio isotopic-labeled compounds for the diagnosis and treatment of cancers. CIL is an operating business owned by Otsuka Pharmaceutical. The CIL business consists of two facilities in the Boston, MA, area; a large isotope-enrichment production plant in Xenia, OH; CIL China; CIL Canada; ABX in Dresden, Germany; and Eurisotop in Saclay, France. For more information on CIL, visit isotope.com.

Contact Information
Crissy Krisko
crissyk@isotope.com
1.978.269.1930

SOURCE: Cambridge Isotope Laboratories, Inc.

Cambridge Isotope Laboratories, Inc. Expands 13C Production Capacity With North Star Project

Cambridge Isotope Laboratories, Inc. (CIL), the global leader in 13Cand 13C urea production, is excited to announce the startup of its North Star project, significantly increasing the company’s production capabilities.

The North Star project commenced in mid-2020 as the world’s largest 13C production cascade. After the complex build of phase one finished in March 2024, CIL began to introduce naturally abundant product into the front end of the distillation cascade. With each stage of the cascade, the predicted enrichment has exceeded expectations, and the overall performance has been exceptional. The first highly enriched 13C finished product will be captured in October of 2024. CIL will build more front-end systems to bring final production of the cascade to world scale capacities by April 2025.

“This is CIL’s fourth 13C production system since 1990. With each system, our team of talented engineers have incorporated their 30-plus years of design, operation, and construction experience into the next system. Our North Star cascade is certainly proving that knowledge and experience pays impactful dividends for CIL and our customers,” said Cliff Caldwell, CEO of CIL.

“CIL’s talented organic chemists incorporate our 13C product into a myriad of labelled organic compounds with significant importance in environmental testing, biopharmaceutical research, and medical diagnostics. One critical product is 13C Urea used in the detection of H-pylori infections in humans. H-pylori is widespread throughout the world and can lead to stomach ulcers and stomach cancer. 13C urea provides a low-cost detection method to allow for treatment and elimination of H-pylori. The North Star project assures CIL’s commitment to meeting the needs of 13C urea and accommodate future growth in other critical applications,” states Mike Steiger, Vice President of Engineering and Project Execution.

For years, CIL has been the go-to expert in cryogenic distillation, solidifying its position as the world’s top producer of 13C isotopes. CIL’s customers can be assured they have the reliable capacity of 13C to meet enable the commercialization of their research.

Contact Information
Crissy Krisko
crissyk@isotope.com
1.978.269.1930

SOURCE: Cambridge Isotope Laboratories, Inc.

Cambridge Isotope Laboratories, Inc. Launches 12C Methane QG Diamond for Quantum Applications

Cambridge Isotope Laboratories, Inc. (CIL) is pleased to announce the release of highly enriched 12C methane with low nitrogen content called 12C Methane QG Diamond™ for quantum applications in the field of color and nitrogen vacancy CVD diamonds. 12C Methane QG Diamond will be useful for academics focused on quantum research, those developing diamonds with specific color properties or nitrogen-vacancy (NV) centers, and producers of industrial diamonds. The process of such applications begins with 12C-enriched methane.

“The creation of NV diamonds necessitates an exceptionally high concentration of 12C; minimal and controlled amounts of nitrogen,” explains Joel Louette, who oversees business development for Emerging Markets at CIL. “Our interactions with clients from both academia and industry lead us to understand that the ideal material would possess a 12C enrichment of no less than 99.99% and contain nitrogen at levels below 1 part per million.”

For over four decades, CIL has honed its skill in separating 13C isotopes through the process of cryogenic distillation. In doing so, CIL has consistently increased its 13C production capabilities to satisfy growing market needs, thereby reinforcing its position as a leader in this sector. Utilizing this deep-seated knowledge in cryogenic distillation, CIL has successfully developed a new 12C separation system, achieving the transition from design to operation in under three years.

Quantum magnetometers based on NV are revolutionizing inertial navigation, enhancing electric vehicle battery efficiency, healthcare, internet security, and may one day enable brain-to-machine interfaces.

About Cambridge Isotope Laboratories, Inc.
CIL is the world’s largest manufacturer and global supplier of stable isotopes and stable isotope-labeled compounds used in research, environmental, neonatal, pharmaceutical, medical diagnostic, OLED, and industrial markets. CIL subsidiary ABX, located in Dresden, Germany, is active in the development and commercialization of radio isotopic-labeled compounds for the diagnosis and treatment of cancers. CIL is an operating business owned by Otsuka Pharmaceutical. The CIL business consists of two facilities in the Boston, MA, area; a large isotope-enrichment production plant in Xenia, OH; CIL China; CIL Canada; ABX in Dresden, Germany; and Eurisotop in Saclay, France. For more information on CIL, visit isotope.com.

Cambridge Isotope Laboratories, Inc.
Phone: 1.978.749.8000
Fax: 1.978.749.2768
www.isotope.com

Contact Information

Crissy Krisko
crissyk@isotope.com
1.978.269.1930

SOURCE: Cambridge Isotope Laboratories, Inc.

View the original press release on newswire.com.

Cambridge Isotope Laboratories (CIL) Shows Long-Term Commitment to Xenia, Ohio, Facility With New Land Purchase

Cambridge Isotope Laboratories, Inc. (CIL) has acquired an additional 14.8 acres of land at its Cambridge Isotope Separations (CIS) Xenia, Ohio location. Mike Steiger, Vice President of Engineering and Project Execution for CIL, stated that the new land purchase will ensure easier access to utilities for future expansion.

This newly acquired land is situated to the west of the 20 acres purchased in 2017, which is currently the site of the North Star expansion project. This recently completed project will greatly increase 13C production and is in the startup phase. North Star is the largest 13C separation facility ever built in the world and will significantly increase CIL’s capacity ensuring customer reliability for this stable isotope.

The land acquired provides the business flexibility to expand in the future as the demand continues to grow worldwide in all applications. “This investment shows CIL’s commitment to innovation and growth for our customers,” said CEO Cliff Caldwell. “CIL works closely with our diverse and global customers to develop and commercialize exciting, high-value applications for isotopically labeled compounds. As these applications commercialize, our customers rely on CIL’s ability to scale our chemistry quickly and reliably. This land acquisition assures we have the space to continue meeting their expectations and enable these technology advancements.”

The CIS facility has the world’s largest 13C separation facility, is one of the world’s largest 18O isotope-separation facilities and houses the largest commercial D2O re-enrichment columns in the world.

Stable isotopes, particularly deuterium, have seen an increase in commercial-scale applications in the last few decades. These applications include pharmaceuticals, semiconductors, flat panel displays, and other high-technology fields. CIL has a three-year supply contract with one Canadian source for D2O, as well as three other sources, and holds an average of an 18-24-month supply in four of CIL locations to ensure the most reliable supply.

About Cambridge Isotope Laboratories, Inc.
CIL is the world’s largest manufacturer and global supplier of stable isotopes and stable isotope-labeled compounds used in research, environmental, neonatal, pharmaceutical, medical diagnostic, OLED, and industrial markets. CIL subsidiary ABX in Dresden, Germany, is active in the development and commercialization of radio isotopic-labeled compounds for the diagnosis and treatment of cancers. CIL is an operating business owned by Otsuka Pharmaceutical. The CIL business consists of two facilities in the Boston, Massachusetts, area; a large isotope-enrichment production plant in Xenia, Ohio; CIL China; CIL Canada; ABX in Dresden, Germany; and Eurisotop in Saclay, France. For more information on CIL, visit isotope.com.

Contact Information
Crissy Krisko
crissyk@isotope.com
1.978.269.1930

SOURCE: Cambridge Isotope Laboratories, Inc.

View the original press release on newswire.com.

Cambridge Isotope Laboratories, Inc. (CIL) Announces Relocation of Corporate Headquarters and Expansion of Research & Development and cGMP Production

New Location Positions CIL for Product Development and Future Growth

Cambridge Isotope Laboratories, Inc. (CIL), the world leader in stable isotope chemistry and the separation of carbon-13 (13C), has announced it will be relocating and expanding its corporate headquarters to newly purchased space in Tewksbury, MA, to advance the operations and growth of the company. The purchase was made in June 2023.

The new location is a two-building, 150,000-square-foot campus with 25 lakefront acres at 100 & 200 Ames Pond Drive. The Ames Pond campus will be the home of a new 8,000-square-foot research and development (R&D) facility and will significantly expand cGMP, QC, formulations, and production labs. The spacious facility will provide CIL with the opportunity to cultivate a dynamic work environment for its valued employees, enabling cross-functional teams to collaborate seamlessly.

“Stable isotope-labeled compounds are in high demand in the market. This expansion provides CIL the space to develop new products and invest in advanced analytical and production technologies,” states CIL’s Chief Science Officer (CSO) Todd Osiek. “The new R&D facility will include organic chemistry space as well as a development/scale-up lab with multiple walk-in hoods.”

The GMP facility will more than double the existing space. Marwan ElMasri, Director of GMP Production, adds, “With this expansion, CIL will be able to produce metric ton quantities of commercial-grade APIs labeled with stable isotopes. This expansion will dramatically improve our capabilities for producing larger scale stable isotope-labeled materials for clinical trials. Our increased production capacity will certainly enable us to better serve our customers and partners.”

CEO Cliff Caldwell adds, “The Ames Pond development, in addition to providing a highly desirable work campus for our employees, elevates our research and development efforts, significantly expands our GMP production capacities, improves operational efficiency, and enhances our ability to innovate for our customers.”

CIL will continue operating its existing headquarters at 3 Highwood Drive, Tewksbury, MA, and production facility located 50 Frontage Road in Andover, MA. The 3 Highwood Drive facility will transition to Ames Pond as construction is completed. CIL’s Andover production location will remain operational after the move.

About Cambridge Isotope Laboratories, Inc.
CIL is the world’s largest manufacturer and global supplier of stable isotopes and stable isotope-labeled compounds used in research, environmental, neonatal, pharmaceutical, medical diagnostic, OLED, and industrial markets. CIL subsidiary ABX, located in Dresden, Germany, is active in the development and commercialization of radio isotopic-labeled compounds for the diagnosis and treatment of cancers. CIL is an operating business owned by Otsuka Pharmaceutical. The CIL business consists of two facilities in the Boston, MA, area; a large isotope-enrichment production plant in Xenia, OH; CIL China; CIL Canada; ABX in Dresden, Germany; and Eurisotop in Saclay, France. For more information on CIL, visit isotope.com.

Contact Information
Crissy Krisko
crissyk@isotope.com
1.978.269.1930

SOURCE: Cambridge Isotope Laboratories, Inc.

View the original press release on newswire.com.