More Impactful Partnership to Address Asia’s ‘Gathering Food Security Storm’ Urged by Regional Plant Science Industry

CropLife Asia makes appeal to Region’s Food Supply Stakeholders with kickoff of FAO APAC Meetings

As the Food and Agriculture Organization (FAO) of the United Nations (UN) convened virtually to begin its Regional Conference for Asia and the Pacific, CropLife Asia took the opportunity to raise the growing threat posed by a number of factors to the region’s food supply and the critical need for shared, sustainable solutions driven by stakeholder collaboration across the food value chain.

“Our regional supply of safe and nutritious food is being threatened like never before,” said Dr. Siang Hee Tan, CropLife Asia Executive Director. “These unprecedented times call for an unprecedented response — including strong partnership among the region’s food supply stakeholders.

“In the fields, regional farmers are contending with limited natural resources, increasingly erratic weather, and a greater number of weeds, diseases and pests with which to contend. Sadly, the COVID-19 pandemic has only added to the pressure on our regional growers as well as the larger food supply chain.

“The meetings this week are a great opportunity to bring our regional food supply stakeholders closer together in delivering shared solutions. It’s critical that we use this opportunity to drive more impactful partnership across the food supply chain and meet the challenges posed by the gathering food security storm we face in Asia.”

Earlier this year, the UN’s 2020 State of Food Security & Nutrition in the World concluded that almost 690 million globally went hungry in 2019. The research also indicated that Asia is home to the greatest number of undernourished people.

In another policy brief released by the UN recently, The Impact of COVID-19 on Food Security and Nutrition, serious concerns were also raised regarding the effect COVID-19 is having globally on the most vulnerable parts of society already experiencing hunger and malnutrition.

Plant science continues to play a crucial role in helping feed our growing global population. Biotech crops are developed with improved traits such as increased yield, better resistance to pests and/or improved nutrition, among others. These traits are important tools that enable farmers to meet global challenges such as food insecurity. Meanwhile, farmers continue to rely on crop protection products to produce more food on less land and raise productivity per hectare. Without crop protection products, 40 percent of global rice and maize harvests could be lost every year and losses for fruits and vegetables could be as high as 50-90 percent.

About CropLife Asia
CropLife Asia is a non-profit society and the regional organization of CropLife International, the voice of the global plant science industry. We advocate a safe, secure food supply, and our vision is food security enabled by innovative agriculture. CropLife Asia supports the work of 15 member associations across the continent and is led by six member companies at the forefront of crop protection, seeds and/or biotechnology research and development. For more information, visit us at www.croplifeasia.org.

For more information please contact:
Duke Hipp
Director, Public Affairs & Strategic Partnerships
CropLife Asia
Tel: +65 6221 1615
duke.hipp@croplifeasia.org

GOME’s “Home Living” Strategy Speeds Up at Its All-out Efforts

Entered into the Second Phase of Strategical Development to Create GOME’s Own Integrated Online and Offline Retail Ecosystem

GOME Retail Holdings Limited (493.HK) today announced its unaudited interim results for the six months period ended 30 June 2020 (the “Reporting Period”).

“Home Living” Strategy Speeds Up at Its All-out Efforts and Successfully Completed the First Phase of Strategical Development

In the first half of 2020, the Group implemented steadily the strategy of developing into an Internet-based enterprise and strived to become an integrated solution, service solution and supply chain provider. During the Reporting Period, GOME made full use of the innovative platform of “Community + GOME APP” to capture chances brought by the rapid transformation of consumption pattern in “Stay Home Economy” and promote significantly the cash conversion rate of social media based online channels. As a result, the GMV of “Community + GOME APP” with GOME Retails’ genes grew by more than 70% year-on-year (“yoy”) and daily GMV occasionally exceeded RMB 1 billion. During the Reporting period, the number of online communities of the Group grew by over 40% yoy, representing a 65% increase yoy.

Explore Continuously New Retail Model and Create GOME’s New Growth Engine of Quality Live Streaming

During the Reporting Period, GOME has developed proactively its community marketing and leveraged fully GOME’s advantages on supply chain, logistics and community social interaction. As a result, the cash conversion rate of GOME online community reached 30%, significantly higher than the industry average, increasing by more than 150% yoy. Additionally, GOME capitalized on its resources and capabilities, creating a quality live streaming model characterized by “Knowledge-based contents + Premium IP with huge traffic + Immersive scenario”. In the first half of 2020, the Group already hosted over 2,000 live streaming events with various themes and scale, reaching over 100 million people. During the Reporting Period, in four of the super live streaming events, the Group’s sales revenue reached RMB2,500 million in total. In the second half of this year, the Group will continue to cooperate with top media platforms – CCTV News, and launch steadily live streaming events across 31 provinces nationwide, showcasing GOME’s “New Growth Engine” and its localized retail model to consumer across the country.

Open Supply Chain, Introduced Two Strategic Partners to Enjoy Mutual Benefits through Collaboration

The Group entered into strategic cooperation agreements with JD.com and Pinduoduo.com in the first half of the year. As of now, all parties have deployed in-depth cooperation at different areas. During the Reporting Period, the GMV of the Group generated from JD.com, Pinduoduo.com and other e-commerce platforms grew more than 100 times yoy. In August 2020, GOME and JD.com have strengthened their cooperation by signing up the joint procurement with an aggregate amount of RMB30 billion. This was ranked the largest year to date procurement in the home appliance and 3C industry in China. At the same time, GOME has been offered access to more than 20,000 non-home appliances SKU from JD.com. This line-up is expected to facilitate the sales of GOME’s full range of products. GOME will utilize the in-depth cooperation with JD.com and Pinduoduo.com to share edge resources from each other, develop continuously new retail model with online and offline integration, as well as realize greater synergy effects.

Coped Actively with the Impact of Pandemic and Cash-on-hand Maintained at a Healthy Level

The Group’s large home appliance business, which was affected seriously by COVID-19, recovered in the second quarter this year as reflected by a quarter-on-quarter increase of 103% in its sales revenue. On a positive note, sales revenue generated from large home appliance business remained resilient in June 2020 as compared with the corresponding period last year. In addition, overall gross profit margin also showed a trend of month-on-month recovery since the second quarter this year and rebounded to the pre-pandemic level of 16%. Moreover, the operating cost was reduced by 26% yoy. With regard to financial strength, the Group maintained sufficient capital after the full repayment of US$500 million overseas bonds during the Reporting Period. The Group’s cash and cash equivalents amounted to approximately RMB11.4 billion as at June-end, illustrating a healthy financial position.

Entered into the Second Strategic Phase of Open Sharing and Constructed GOME’s Own Integrated Online and Offline Retail Ecosystem

In the first half of this year, the Group’s business was impacted by the novel coronavirus outbreak. However, the Group withstood this stress test and successfully achieved the goal of the first phase of strategic development. Going forward, the Group will ride on its 33 years of industry experience and break new grounds in a bid to construct an integrated online and offline retail ecosystem featuring Social Interaction + Commerce + Sharing. GOME is the only enterprise in China with online and offline dual platform focused on “Social Interaction + Commerce + Sharing” covering a wide of products. With regard to offline platform, the Group has established a huge team of approximately 100,000 staffs, spanning across over 2,800 stores in the country. Leveraging the physical store as the center and the community in a grid network, the Group provides its services to users within three to five kilometers. Besides, leveraging the staff as the link, the Group realizes the face to face social communication with users. Turning to online platform, the Group owns e-commerce channels which supports the localized operational development, social sharing platforms, extensive communities and widespread users. In the past, by taking advantages of these resources, the Group maintained its leading position in vertical integrated home appliances sector. For future growth, the Group will be more open-minded to enter into the second phase of strategic development with a goal of achieving win-win synergy.

Focus on Local Retail and Create a New GOME Oriented by User, Platform and Technology

Capitalizing on the solid foundation of its current home appliances sales business, the Group plans to increase the business volume mainly through platforms, servicing external enterprises and the whole society. On the online platform, the Group will support the development of enterprises by empowering traffic, SaaS and intelligent management and decision system. Regarding the empowerment of traffic, the Group will share with the third parties its accumulated high-quality traffic with high conversion rate to facilitate their business development. With regard to the empowerment of SaaS, the Group will utilize its local retail operation and adopt the mode “one store one webpage” at the store end, “one community one webpage” at the community end, and “one people one webpage” at the user end to achieve coordinated development, significantly reducing their operation costs and helping them to diverse online traffic to offline. In the meantime, by offering digitalized artificial intelligence management tools, the Group will help them to enhance enterprise decision making and operation efficiency. In tandem with the ever-changing consumption pattern, online transaction has become a pronounced development trend. Therefore, e-commerce operation will emerge as the triggering point and remote control of industry development. The two core elements of offline platform were the showcase of quality products and life services. The Group will leverage fully the competitive advantages of its store network and provide strategic support selectively to those online enterprises which do not have offline outlets to showcase their quality products and associated scenarios. Moreover, the Group will strive to improve the offline supply chain operational efficiency of these enterprises by over 40%. Meanwhile, underpinned by various offline scenarios, the Group intends to bring in new operation model and content of home services. With the extension of home scenarios, namely living room, dining room, kitchen and showroom, and the theme of entertainment-styled marketing, the Group will provide users with various services related to catering, entertainment, shopping, leisure, etc., in the offline platform. Moreover, as a social interaction venue, the offline platform also provides users with quality time in social communication, meeting, relaxing and family gathering, thereby satisfying different demands from members of various ages and classes and of different families within the community. With its professional service team, GOME’s offline stores are able to provide comprehensive scenarios of In-store and In-home services at different time throughout the day. Leveraging the marketing of gridded community backed by life services and selected quality product showcases will render users in the community to become the loyalty member of GOME’s platforms, which serve users’ daily consumption needs and become cash conversion drivers.

Construct Diversified Vertical Supply Chain System through Stringent Selection

GOME will continue to strengthen its leading position in home appliances sector by deploying high efficiency and low-cost operation models. Moreover, the Group will continue to build up the supply chain system of home appliances with the advantages of rich product mix and bargaining prices. This would spearhead the Group to raise its market shares, regain its original position in the market and realize greater profitability in the shortest possible time. The Group strives to increase the number of offline stores by 20% next year or the first half of 2022 and realize the promotion of sales scale and profitability. In addition, the Group plans to share with the third parties its supply chain edges. This would be achieved by opening its supply chain system to the strategic partners and franchises in low tier markets. Leveraging the expansion drive of supply chain cooperation between the Company and strategic partners with same open-minded approach, this would enable all parties to consolidate their resources and create more opportunities through multiple channel sales, thus generating win-win situations for all parties. In third-tier to sixth-tier cities, the Group will continue to employ its asset-light business model to speed up the franchise expansion and explore profoundly the market potentials.

Meanwhile, the Group plans to expand its product mix to non-home appliance products through stringent selection. The Group currently completed the self-operated vertical sales trial of fresh foods, hotpot foods and home decoration services in its full industry chain. The Group has fine-tuned the operational process and improved the business model during these trials. The management expected to beef up efforts to promote such businesses in the future. Stringent selection use strict selection standard to further develop the integration advantages of upstream supply chain, expanding the customized category and scale. By providing the best quality goods and services, GOME can form a deep traffic interactive platform, transforming high-quality private sector traffic into public sector traffic of the platform, and improve the conversion rate of the platform.

All business segments in the “Dual Platforms” ecosystem are expected to benefit from mutual complement, connection and interaction. Both users and retailers would be served by rapid developing models such as panic-buying in social media, bonus sharing, entertainment-styled marketing and one store one webpage strategy. This in turn would bring about cash conversion. All platforms would share information and all retailers in the platforms would converge their traffic. Thus, the private sector traffic would precipitate the inflow of public sector traffic, thereby creating a virtuous cycle of expansion.

Mr. Wang Junzhou, Chief Executive Officer of GOME concludes: “In the first half of 2020, the Group has continued to uphold the spirit of persevering amidst adversities and overcame the difficulties and challenges from the pandemic. Meanwhile, the Group has further enhanced its capabilities on business operation and the scope of services in virtue of its advantages gained over the years. In the future, the Group will consolidate and optimize its existing resources in order to exert the ‘multiplier effect’ and gain more resources, enabling the ‘leaping’ transformation from the self-operated retailer to become GOME ecosystem combining online and offline platform. GOME is the only domestic online and offline enterprise with full category of online and offline platforms, which is focused on ‘Social Interaction + Commerce + Sharing’. In the past, we have been leading the industry in the vertical field of household appliances around price advantage, service standard and brand reputation. Now, we are going to enter the second stage of strategy faster and more openly, with full confidence and expectation: focus on local retail, and create a new GOME oriented by user, platform and technology”.

China Risun Announces 2020 Interim Results

Expand Operating Management Business to East China Region
Hydrogen Production Facility Commences Operation

China Risun Group Limited (“China Risun”, or the “Group”, stock code: 1907), the global leading integrated coke, coking chemical and refined chemical producer and supplier in China, has announced its interim results for the six months ended 30 June 2020 (“1H2020” or “the reporting period”).

Affected by the outbreak of COVID-19 and the decrease in international oil price, during the reporting period, the Group’s revenue recorded at RMB8,133.1 million. Gross profit amounted to RMB1,157.2 million and gross profit margin increased slightly to 14.2%. Profit attributable to owner of the Company was approximately RMB351.0 million. Basic earnings per share was RMB8.58 cents. Cash and cash equivalents amounted to RMB929.4 million.

To reward shareholders for their continuous support, the Board determined an interim dividend of RMB2.58 cents per share, with total interim dividend amount of approximately HK$119.4 million.

Leverage existing coal chemicals production capacity to tap into hydrogen market at lower production cost

The Group believes that hydrogen is one of the major strategic directions for the PRC’s energy transformation and the Group has huge advantage in refining the coking coal which contains hydrogen chemical element. By making use of its existing coal chemicals production capacity, the Group plans to focus on the pure hydrogen production and utilisation where the production bases are located at. During the reporting period, the Group co-operated with the People’s Government of Dingzhou City in relation to the production, storage and transportation of hydrogen and the construction and operation of hydrogen refueling stations. Such pure hydrogen production facility commenced to operation in July 2020.

In addition, we actively optimized the product portfolio of the refined chemical business and focused on products with positive market expectations. In Tangshan production base, the new styrene production project, which possesses annual production of 300,000 tons and was under construction since 2019, will commence production by the end of 2020.

Further strengthening leading position via JV and operation management services

By leveraging its vertically integrated production chain and extensive experience of more than 25 years in the coal chemical industry, the Group will continue to tap into the downstream refined chemicals markets, aiming of developing more sustainable and striving for the best benefits for all of its stakeholders.

During the Reporting Period, the Group obtained all necessary approvals from the People’s Governments in Liaoning Province and Lingyuan City after the establishment of a joint venture with Lingyuan Iron & Steel Co., Ltd. in December 2019 and subsequently consolidated into the Group after establishment. It is expected that the construction will commence in the second half of 2020.

Furthermore, the Group entered into one new operating management agreement with an independent third party in Jiangxi Province with annual coke production capacity of 1,300,000 tons. The project jn Jiangxi Province hallmarked a new phase that for the first time the Group has expanded its operation and management business footprint into the East China region. It also laid a solid foundation for the Group to further explore the local market. Meanwhile, several new operating management projects are proceeded steadily. Regarding to the new trading company established in Japan, the Group started to import coke from Japanese coke producers, which is remarkable in its history. The Group aimed to expand its trading business from merely export to import & export in future to increase its influence in international trading market.

Looking forward, the Group will continue increasing its market share especially through both light and heavy asset approaches and further expand coke production business. For the refined chemicals, the Group is examining the whole refined chemicals production chain to further develop high potential products e.g. caprolactam to enhance profitability. With an aim of strengthening its leading position as a global coke and refined chemicals producer and supplier, the Group will make use of establishment of new subsidiaries/joint ventures, acquisition of existing coke and refined chemicals producers together with provision of operation management services to third parties in different provinces of China.

About China Risun Group Limited
China Risun Group Limited is the world’s largest independent producer and supplier of coke by volume in 2019, according to Frost & Sullivan. The Group is an integrated coke, coking chemicals and refined chemicals producer and supplier in China and holds leading positions in a number of refined chemicals sectors both in China and globally. The vertically-integrated business model together with more than 25 years of experience in the coal chemicals industry production chain has enabled the Group to further tap the downstream refined chemicals markets and hence diversify its income sources and create greater value.

China Risun has been listed on the main board of the Hong Kong Stock Exchange since March 2019 and is now included in various index series, including Hang Seng Composite Index, Hang Seng Stock Connect Hong Kong Index, Hang Seng Stock Connect Hong Kong MidCap & SmallCap Index, Hang Seng Stock Connect Hong Kong SmallCap Index, Hang Seng SCHK Mainland China Companies Index, and Hang Seng SCHK ex-AH Companies Index. For more details, please visit http://www.risun.com/En/

CDS Chain’s STO application approved by the U.S. SEC

Commercial Data Storage [CDS] application for token offering [STO] has been approved by the U.S. Securities and Exchange Commission [SEC], with the filing available online at SEC’s public database, EDGAR. CDS is a smart agreement based on POTS (Proof of Traffic-measured Storage) consensus technology and focusing on distributed data commercial storage.

CDS’ consensus design combines the IPFS distributed technology concept and the needs of financial data flow with POTS-based flow storage consensus technology. Through the design and recording of intelligent contracts and the preservation of digital information and content of CDS-based financial transactions, CDS can enhance confidentiality and security while realizing the capitalization of personal data.

CDS focuses on commercial data storage agreements, and is committed to realizing a solution of trust, security and efficiency in global business transactions while promoting the development of commercial business. At this stage, CDS focuses on value trading services, while in future it will essentially promote a two-way development of transaction services between commercial transactions and financial institutions.

CDS, as a new protocol following financial data flows, has an on-chain storage and call system encrypted with blockchain technology. A central characteristic of this data system effectively integrates the coexistence of enterprise data producers with distributed data carriers.

The approval and publication of the CDS registry and filing, and CDS’ compliance with SEC regulation in the future, will lead to a more balanced STO in which investors will be more secure. The STO will be a milestone event for CDS on the road to globalization.

Crise Wong, service@cdschain.com, www.cdschain.io,
SEC CIK: 0001822768; SEC Report: https://sec.report/Document/0001822768-20-000001/
SEC Filing: https://www.sec.gov/cgi-bin/browse-edgar?action=getcompany&CIK=0001822768

Aptorum Group Announces Further Positive Data on ALS-4 against MRSA Wound Infection and MRSA Bacteraemia against Linezolid and Vancomycin Respectively in In Vivo Models

Aptorum Group Limited (NASDAQ: APM, Euronext Paris: APM) (“Aptorum Group”), a biopharmaceutical company focused on novel therapeutics including the development of next-generation approach therapeutics targeting antimicrobial resistance, announced two sets of positive data showing both significant in vivo activities of its lead compound ALS-4 against Methicillin-Resistant Staphylococcus aureus (MRSA, one of the “super-bugs”) in wound infected and bacteraemia mouse models, respectively when compared to prevailing antibiotics.

ALS-4 is currently undergoing final stages of IND enabling studies, which involves a 14-Day oral toxicity in rats and dogs, a functional observation battery study in rats and a cardiovascular telemetry and respiratory study in dogs. Subject to the final IND-enabling studies results, ALS-4 is on track to target the regulatory submission in Q4 2020 subject to which to commence Phase I clinical trials in Canada.

“Despite the two current mainstay treatments, vancomycin and daptomycin, being the only FDA approved antibiotics for MRSA bacteraemia thus far, patient mortality, morbidity and recurrence rates remain significant1. With the fragile antibiotic pipeline being at risk globally, antimicrobial resistance issues continue to gain significant attention from global bodies including the World Health Organization and the FDA, as well as the pharmaceutical industry. We believe that our oral ALS-4 drug based on a novel first-in-class anti-virulence concept can potentially tackle a variety of infections related to MRSA, including (but not limited to) bacteraemia and skin & soft tissue infections, subject to the respective clinical trials. We are greatly encouraged by the data because ALS-4 appears to be effective against MRSA superbug and could be a potential alternative and sustainable treatment for different MRSA indications including, but not limited to, MRSA bacteraemia and skin infections. ALS-4’s anti-virulent properties are a novel approach in tackling antimicrobial resistance issues as encouraged by recent global action plans. We are also pleased to report that our IND enabling studies are also at their final stages and we remain on track to target regulatory submission to commence phase 1 clinical trials,” said Mr. Darren Lui, President and Executive Director of the company.

Efficacy of ALS-4 in a MRSA Wound Infection Mouse Model
A recent study, conducted by a third party contract research organization, assessed ALS-4’s effect in the healing of open wounds infected with MRSA in a mouse model. Compared with topical dosing of 2% Mupirocin and oral dosing of Linezolid at 100mg/kg twice a day, oral dosing of ALS-4 at 30mg/kg twice a day showed statistically significant improvement in wound healing. Specifically, at the end of the study on Day 7, ALS-4 exhibited 63.8% of wound closure compared with 48.4% for oral Linezolid and 43.2% for topical Mupirocin 2%. The results are further illustrated in the graph below.

Efficacy of ALS-4 in a Bacteraemia Mouse Model
In a further round of in vivo studies, conducted by a third party contract research organization, in a non-lethal MRSA bacteraemia mouse model, the mice were orally administered with different doses of ALS-4 from 0.3 to 30mg/kg twice a day for 7 days, compared to those who received vancomycin only group (3mg/kg of vancomycin administered intravenously) and a no treatment control group.

At the conclusion of the study on Day 7, ALS-4 brought a statistically significant reduction in bacterial counts in major organs such as the kidneys, lungs, liver and spleen compared with the no drug control and vancomycin only groups (unpaired student’s t-test, p<0.05). This is in addition to the previous in vivo results announced in February 2020, whereby ALS-4 demonstrated on a statistically significant basis better survival rates (56% vs 0% control group) in the lethal MRSA bacteraemia rat model and higher reduction of bacterial load (by 99.5% against the control group) in the non-lethal MRSA bacteraemia rat model.

About ALS-4
As part of Aptorum Group’s Acticule infectious disease platform, ALS-4 is a novel first-in-class small molecule developed in oral form based on an anti-virulence approach targeting Methicillin resistant Staphylococcus aureus (MRSA). ALS-4 targets the antimicrobial resistant properties of S. aureus and render the bacteria to become highly susceptible to the host’s immune clearance and also potentially other existing antibiotics, as shown in the preclinical data.

About Aptorum Group Limited
Aptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) is a pharmaceutical company dedicated to developing and commercializing novel therapeutics to tackle unmet medical needs. Aptorum Group is pursuing therapeutic projects in orphan diseases, infectious diseases, metabolic diseases, woman’s health and other disease areas.

For more information about Aptorum Group, please visit www.aptorumgroup.com.

For further general presentation, please visit: https://ir.aptorumgroup.com/static-files/ca36cc65-6f23-4105-895e-f5f234ecca1e

Disclaimer and Forward-Looking Statements

This press release does not constitute an offer to sell or a solicitation of offers to buy any securities of Aptorum Group.

This press release includes statements concerning Aptorum Group Limited and its future expectations, plans and prospects that constitute “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. For this purpose, any statements contained herein that are not statements of historical fact may be deemed to be forward-looking statements. In some cases, you can identify forward-looking statements by terms such as “may,” “should,” “expects,” “plans,” “anticipates,” “could,” “intends,” “target,” “projects,” “contemplates,” “believes,” “estimates,” “predicts,” “potential,” or “continue,” or the negative of these terms or other similar expressions. Aptorum Group has based these forward-looking statements, which include statements regarding projected timelines for application submissions and trials, largely on its current expectations and projections about future events and trends that it believes may affect its business, financial condition and results of operations. These forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions including, without limitation, risks related to its announced management and organizational changes, the continued service and availability of key personnel, its ability to expand its product assortments by offering additional products for additional consumer segments, development results, the company’s anticipated growth strategies, anticipated trends and challenges in its business, and its expectations regarding, and the stability of, its supply chain, and the risks more fully described in Aptorum Group’s Form 20-F and other filings that Aptorum Group may make with the SEC in the future, as well as the prospectus that received the French Autorite des Marches Financiers visa n20-352 on 16 July 2020.

As a result, the projections included in such forward-looking statements are subject to change and actual results may differ materially from those described herein. Aptorum Group assumes no obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.

This announcement is not a prospectus within the meaning of the Regulation (EU) n2017/1129 of 14 June 2017 as amended by Regulations Delegated (EU) n2019/980 of 14 March 2019 and n2019/979 of 14 March 2019.

This press release is provided “as is” without any representation or warranty of any kind.
https://link.springer.com/article/10.1186/s13054-017-1801-3

Contacts
Investor relations
Aptorum Group limited
Investor Relations Department:
Tel: +44 020 80929299
Email: investor.relations@aptorumgroup.com

Redchip – Financial Communications United States
Investor relations
Dave Gentry
dave@redchip.com
+1 407 491 4498

Actifin – Financial Communications Europe
Investor relations
Ghislaine Gasparetto
ggasparetto@actifin.fr
+33 1 56 88 11 22

Aptorum Group Announces Further Positive Data on SACT-1 Against Neuroblastoma and Other Potential Tumor Types

Aptorum Group Limited (NASDAQ: APM, Euronext Paris: APM) (“Aptorum Group”), a biopharmaceutical company focused on the development of novel therapeutics including orphan diseases and oncology indications, announced further positive data from its latest in vivo studies showing significant activity against neuroblastoma tumor reduction when treated with its lead compound SACT-1 in combination with standard of care (SOC) chemotherapy. Separately, SACT-1 was also screened for its in vitro activity against over 300 cancer cell lines and showed positive results in a number of cancer types including in particular colorectal cancer, leukemia and lymphoma, etc.

Our repurposed drug candidate, SACT-1 is undergoing preparation for IND submission and is on track for regulatory application to target to commence phase 1b/2a clinical trials under the US FDA’s 505(b)(2) pathway.

“Neuroblastoma is one of the most prevailing solid tumor cancers in children, representing 8% – 10% of all childhood tumors, accounting for c. 15% of all cancer related deaths in the pediatric population1. For the high-risk patient group, the 5-year survival rate of this condition is around 40-50% as observed by the American Cancer Society2 based on existing treatment. We are delighted to see the progress of our SACT-1, one of our first assets from our SMART-ACT platform. We are extremely excited to observe SACT-1’s significant effect on tumor shrinkage when used in combination with standard of care chemotherapy in our latest in vivo studies. Moreover, we believe that SACT-1 may have potential applications in a number of other cancer types, including non-orphan cancers, which we will be continuing to investigate further for its wider application,” said Dr. Clark Cheng, the Chief Medical Officer and Executive Director of the company.

Summary of our in vivo assessment against neuroblastoma and in vitro assessment against other cancers are discussed below.

Neuroblastoma In Vivo Assessment
Based on the initial 22 day data of a recent study we conducted in a xenograft mouse model of neuroblastoma, SACT-1 was orally administered daily at 60mg/kg in combination of SOC chemotherapy brought a statistically significant tumor shrinkage (unpaired student’s t-test, p<0.01) from Day 15 to Day 22, compared to the control group which received SOC only. Indeed, the combination reduced the tumor size by up to 54.2% in the first 22 days compared with the control (SOC only). SACT-1 appears to be effective in accelerating the effect of the SOC in early time points (from Day 1 – 7 vs control). This further supports our earlier in vitro observation that SACT-1 promotes tumor DNA damage and tumor cell death.

Other Cancer Types In Vitro Assessment
In addition, SACT-1 was also screened for in vitro activity in a panel of over 300 cancer cell lines. Similar to our previous findings against neuroblastoma cell lines, SACT-1 exhibits similar anti-tumor efficacy across one or more other major cancer types, including but not limited to colorectal cancer, leukemia and lymphoma cell lines. As a result, in addition to treating neuroblastoma, SACT-1 may have potential applications in the treatment of other cancers. Based on this discovery, the company plans to carry out further in vivo studies to study the efficacy of SACT-1 over other types of cancers to maximize the potential of SACT-1.

About SACT-1
As part of Aptorum Group’s SMART-ACT platform, SACT-1 was discovered from our SMART-ACT platform focused on orphan and unmet diseases. SACT-1 is a repurposed drug targeted for the treatment of neuroblastoma (and potentially other cancer types) especially in combination with SOC chemotherapy. SACT-1’s mechanism has been demonstrated in vitro to enhance DNA damage and tumor cell death.

About Aptorum Group Limited
Aptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) is a pharmaceutical company dedicated to developing and commercializing novel therapeutics to tackle unmet medical needs. Aptorum Group is pursuing therapeutic projects in orphan diseases, infectious diseases, metabolic diseases, woman’s health and other disease areas.

For more information about Aptorum Group, please visit www.aptorumgroup.com.

For further general presentation, please visit: https://ir.aptorumgroup.com/static-files/ca36cc65-6f23-4105-895e-f5f234ecca1e

Disclaimer and Forward-Looking Statements

This press release does not constitute an offer to sell or a solicitation of offers to buy any securities of Aptorum Group.

This press release includes statements concerning Aptorum Group Limited and its future expectations, plans and prospects that constitute “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. For this purpose, any statements contained herein that are not statements of historical fact may be deemed to be forward-looking statements. In some cases, you can identify forward-looking statements by terms such as “may,” “should,” “expects,” “plans,” “anticipates,” “could,” “intends,” “target,” “projects,” “contemplates,” “believes,” “estimates,” “predicts,” “potential,” or “continue,” or the negative of these terms or other similar expressions. Aptorum Group has based these forward-looking statements, which include statements regarding projected timelines for application submissions and trials, largely on its current expectations and projections about future events and trends that it believes may affect its business, financial condition and results of operations. These forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions including, without limitation, risks related to its announced management and organizational changes, the continued service and availability of key personnel, its ability to expand its product assortments by offering additional products for additional consumer segments, development results, the company’s anticipated growth strategies, anticipated trends and challenges in its business, and its expectations regarding, and the stability of, its supply chain, and the risks more fully described in Aptorum Group’s Form 20-F and other filings that Aptorum Group may make with the SEC in the future, as well as the prospectus that received the French Autorite des Marches Financiers visa n20-352 on 16 July 2020.

As a result, the projections included in such forward-looking statements are subject to change and actual results may differ materially from those described herein. Aptorum Group assumes no obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.

This announcement is not a prospectus within the meaning of the Regulation (EU) n2017/1129 of 14 June 2017 as amended by Regulations Delegated (EU) n2019/980 of 14 March 2019 and n2019/979 of 14 March 2019.

This press release is provided “as is” without any representation or warranty of any kind.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668791/#:~:text=Neuroblastoma%20is%20the%20most%20common,deaths%20in%20the%20pediatric%20population.
https://www.cancer.org/cancer/neuroblastoma/detection-diagnosis-staging/survival-rates.html

Contacts
Investor relations
Aptorum Group limited
Investor Relations Department:
Tel: +44 020 80929299
Email: investor.relations@aptorumgroup.com

Redchip – Financial Communications United States
Investor relations
RedChip Companies, Inc.
dave@redchip.com
+1 407 491 4498

Actifin – Financial Communications Europe
Investor relations
Ghislaine Gasparetto
ggasparetto@actifin.fr
+33 1 56 88 11 22

Aptorum Group Limited Reports Financial Results and Business Update for the Six Months Ended June 30, 2020

Aptorum Group Limited (NASDAQ: APM, Euronext Paris: APM) (“Aptorum Group”or the “Company”), a biopharmaceutical company focuses on the development of novel therapeutics to address global unmet medical needs, today provided a business update and announced financial results for the six months ended June 30, 2020.

“I am pleased with the developments that were achieved during the first half of 2020 despite the challenges presented by the COVID-19 pandemic,” said Mr. Ian Huen, Chief Executive Officer and Executive Director of Aptorum Group. “Throughout the COVID-19 crisis, we remained focused on advancing the development of our therapeutic programs. As announced today, further positive data showing significant in vivo activities of ALS-4 (for MRSA wound healing and MRSA bacteraemia) and also in vitro and in vivo studies of SACT-1 (for neuroblastoma and other potential tumor types). Also, as an emerging company, we have been expanding our global strategic presence. In July, Aptorum Group became the first Nasdaq listed biopharmaceutical company admitted to trading on Euronext Paris. We are also delighted about 3 new appointments we made to support the development of our various programs. Looking forward, we remain committed to accelerating the Company’s commercial growth and transformation into a biopharmaceutical company with exciting clinical stage assets being developed.”

Clinical Pipeline Update and Upcoming Milestones
SACT-1-lead program of the Smart-ACTTM platform, a repurposed drug for neuroblastoma and others: Undergoing preparation and on track for IND submission to commence Phase 1b/2a human clinical trials targeting the US FDA’s 505(b)(2) pathway. Further in vitro screening to assess SACT-1’s potential effect on over 300 cancer cell lines has been completed and showed promising effect on including, but not limited to, colorectal cancer, leukemia and lymphoma.

ALS-4-lead program of the Acticule platform, a small drug molecule candidate for methicillin resistant Staphylococcus aureus (“MRSA” superbug): ALS-4 is undergoing final stages of IND enabling studies and is targeted for regulatory submission in Q4 2020 to commence a Phase 1 human clinical trial thereafter.

CLS-1-lead program of the Claves platform, a macromolecule approach for obesity: Currently in lead optimization stage, aimed for IND enabling studies to commence in 2021.

NLS-2 NativusWell-a dietary supplement for woman’s health, including menopause and osteoporosis: Undergoing registration in the United Kingdom, Europe and Asia, aimed for distribution to market in 2020.

Corporate Highlights
Commenced trading on Euronext Paris stock exchange:
Aptorum Group became the first Nasdaq listed biopharmaceutical company admitted to trading on Euronext Paris. The Class A Ordinary Shares of Aptorum Group have commenced trading on the Professional Compartment of Euronext in Paris under the Euronext ticker symbol “APM” and ISIN Code: KYG6096M1069 on 24 July 2020.

Three new personnel appointed to Aptorum Group’s team:
– Dr. Herman Weiss, M.D., Chief Executive Officer and Executive Director of Claves Life Sciences Limited and Senior Medical Advisor of Aptorum Group
– Dr. Kira Sheinerman, Senior Strategic Consultant of Aptorum Group
– Dr. Robbie Majzner, Scientific Advisor of Aptorum Group

Financial Results for the Six Months Ended June 30, 2020
Aptorum Group reported a net loss of $7.0 million for the six months ended June 30, 2020 compared to $9.6 million for the same period in 2019. The decrease in net loss in current period was driven by decrease in interest expenses, net of $3.6 million, partly offset by the increase in research and development expenses by $1.6 million.

Research and development expenses were $4.3 million for the six months ended June 30, 2020 compared to $2.7 million for the same period in 2019. The increase was primarily due to the increase in consultation service provided by our consultants, advisory and contracted research organization as a result of the progress of our projects’ development.

General and administrative fees were $2.1 million for the six months ended June 30, 2020 compared to $3.2 million for the same period in 2019. The decrease was mainly driven by the decrease in bonus related expenses to our directors, employees, external consultants and advisors. Also, there was a significant decrease in business trips and sponsoring conference in 2020 due to the outbreak of COVID-19.

Legal and professional fees were $1.5 million for the six months ended June 30, 2020 compared to $2.0 million for the same period in 2019. The decrease in legal and professional fees was mainly due to the decrease of consultancy service fees during the period.

Interest expenses, net were $0.1 million for the six months ended June 30, 2020 compared to $3.7 million for the same period in 2019. The decrease in interest expenses, net was mainly due to the convertible debts were fully repaid in 2019. The interest expenses, net for the six month ended June 30, 2019 contained $3.1 million amortization of beneficial conversion feature of our convertible debts.

As of June 30, 2020, cash, restricted cash and marketable securities totaled approximately $4.4 million and total equity was approximately $17.5 million.

Aptorum Group expects that its existing cash, restricted cash and marketable securities, together with undrawn line of credit facility from related parties, will enable it to fund its operating and capital expenditure requirements to the end of 2021.

About Aptorum Group Limited
Aptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) is a pharmaceutical company dedicated to developing and commercializing novel therapeutics to tackle unmet medical needs. Aptorum Group is pursuing therapeutic projects in orphan diseases, infectious diseases, metabolic diseases, woman’s health and other disease areas.

For more information about Aptorum Group, please visit www.aptorumgroup.com.

For further general presentation, please visit: https://ir.aptorumgroup.com/static-files/ca36cc65-6f23-4105-895e-f5f234ecca1e

Disclaimer and Forward-Looking Statements

This press release does not constitute an offer to sell or a solicitation of offers to buy any securities of Aptorum Group.

This press release includes statements concerning Aptorum Group Limited and its future expectations, plans and prospects that constitute “forward-looking statements” within the meaning of the US Private Securities Litigation Reform Act of 1995. For this purpose, any statements contained herein that are not statements of historical fact may be deemed to be forward-looking statements. In some cases, you can identify forward-looking statements by terms such as “may,” “should,” “expects,” “plans,” “anticipates,” “could,” “intends,” “target,” “projects,” “contemplates,” “believes,” “estimates,” “predicts,” “potential,” or “continue,” or the negative of these terms or other similar expressions. Aptorum Group has based these forward-looking statements, which include statements regarding projected timelines for application submissions and trials, largely on its current expectations and projections about future events and trends that it believes may affect its business, financial condition and results of operations.

These forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions including, without limitation, risks related to its announced management and organizational changes, the continued service and availability of key personnel, its ability to expand its product assortments by offering additional products for additional consumer segments, development results, the company’s anticipated growth strategies, anticipated trends and challenges in its business, and its expectations regarding, and the stability of, its supply chain, and the risks more fully described in Aptorum Group’s Form 20-F and other filings that Aptorum Group may make with the SEC in the future and the prospectus that received the French Autorite des Marches Financiers visa n20-352 on 16 July 2020. As a result, the projections included in such forward-looking statements are subject to change and actual results could be materially different from those described herein.

Aptorum Group assumes no obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.

This announcement is not a prospectus within the meaning of the Regulation (EU) n2017/1129 of 14 June 2017 as amended by Regulations Delegated (EU) n2019/980 of 14 March 2019 and n2019/979 of 14 March 2019.

This press release is provided “as is” without any representation or warranty of any kind.

Contacts
Investor relations
Aptorum Group limited
Investor Relations Department
Tel: +44 020 80929299
Email: investor.relations@aptorumgroup.com

Redchip – Financial Communications United States
Investor relations
RedChip Companies, Inc.
dave@redchip.com
+1 407 491 4498

Actifin – Financial Communications Europe
Investor relations
Ghislaine Gasparetto
ggasparetto@actifin.fr
+33 1 56 88 11 22

FILMART Online attracts 7,000 international buyers

Multifunctional online platform runs until late September

Organised by the Hong Kong Trade Development Council (HKTDC), the Hong Kong International Film & TV Market (FILMART Online) concluded successfully on 29 August. The four-day virtual content marketplace, where some 2,100 film and television productions were released and promoted, attracted nearly 7,000 international buyers from 73 countries and regions. More than 2,000 online business matching meetings were arranged, illustrating strong demand for entertainment content globally and confidence in the prospects for the industry.

The Hong Kong International Film & TV Market (FILMART Online) concluded successfully on 29 August. The four-day virtual content marketplace attracted nearly 7,000 international buyers, with more than 2,000 online business matching meetings arranged. Various functions of the FILMART Online platform will remain available until 30 September.
Twenty-two online conferences and fringe events took place as part of FILMART Online, drawing more than 35,000 views in total. The photo above shows four speakers at the Digital Entertainment Summit 2020 discussing how the use of 5G, cloud and interactive entertainment technologies can bring a more immersive and personalised experience to the market.

More than 20 fringe events facilitate exchange

A total of 22 fringe events took place as part of FILMART Online, drawing more than 35,000 views in total. Among these events, six online conferences addressed the latest industry developments in areas such as streaming platforms and technologies for developing interactive entertainment content. Representatives from Japan, France, the Philippines, Finland and Taiwan introduced their quality productions and detailed local measures introduced in support of entertainment projects.

Multifunctional online platform continues until late September

Various functions of the FILMART Online platform will remain available until 30 September. Up to and including that date, exhibitors can continue to promote their productions and connect with buyers through the multifunctional online platform, while buyers can search for projects and enjoy online screenings, as well as viewing footage from the online conferences and seminars held as part of the event.

Website: http://www.hktdc.com/hkfilmart
Photo download: https://bit.ly/2EFZhm2

About HKTDC

The Hong Kong Trade Development Council (HKTDC) is a statutory body established in 1966 to promote, assist and develop Hong Kong’s trade. With 50 offices globally, including 13 in Mainland China, the HKTDC promotes Hong Kong as a two-way global investment and business hub. The HKTDC organises international exhibitions, conferences and business missions to create business opportunities for companies, particularly small and medium-sized enterprises (SMEs), in the mainland and international markets. The HKTDC also provides up-to-date market insights and product information via trade publications, research reports and digital news channels. For more information, please visit: www.hktdc.com/aboutus. Follow us on Twitter @hktdc and LinkedIn

Contact:

Sam Ho, Tel: +852 2584 4569, Email: sam.sy.ho@hktdc.org
Cathy Lee, Tel: +852 2584 4393, Email: cathy.wk.lee@hktdc.org

Hepalink Announces 2020 Interim Results

Outstanding Performance in 1H2020
Revenues: +24% YoY;
Profit Attributable to Equity Holders of the Company (Non-IFRS1): +669% YoY

Shenzhen Hepalink Pharmaceutical Co., Ltd. (Stock Code: 9989.HK; “Hepalink” or the “Group”) today announced the unaudited consolidated results for the first half year of 2020 (“1H2020”) ended June 30, 2020 (the “Reporting Period”).

Financial Highlights
For the six months ended 30 June 2020, the Group recorded:
– Total revenue was RMB2,635.6 million, an increase of 24.3% over the first half of 2019 (“YoY”);
– Gross profit was RMB1,085.8 million, an increase of 47.9% YoY;
– Gross margin amounted to 41.2%, an increase of 6.6 percentage point YoY;
– On a non-IFRS basis, net profit attributable to equity holders of the Group (net of non-recurring profit or loss) was RMB505 million, increased by 668.8%;
– The adjusted net profit attributable to equity holders of the Group after deduction of non-recurring profit or loss (excluding the listing expenses after tax of RMB32 million) was approximately RMB 532 million.

In the first half of 2020, the sudden outbreak of COVID-19 has impacted many industries in varying degree. During the Reporting Period, the Group maintained sound revenue growth and profitability. For the six months ended June 30, 2020, the Group’s total revenue amounted to RMB2,635.6 million, representing a year-on-year increase of 24.3%, while the gross profit of the Group increased 47.9% to RMB1,085.8 million; and recorded net profit attributable to equity holders of the Group (net of non-recurring profit or loss) of RMB505 million, representing a year-on-year increase of 668.8%.

Outstanding Performance of Our Businesses
The revenue from finished dose pharmaceutical products business increased by 37.1% to RMB631.3 million for the first half of 2020 on a year-on-year basis and accounted for 24.0% of the Group’s total sales revenue. Gross profit increased by 31.1% to RMB272.8 million, with a gross margin of 43.2%. During the Reporting Period, as the major market of enoxaparin finished dose, Europe was affected by the unexpected COVID-19 epidemic, and the Group encountered varying degrees of challenges. The Group proactively strengthened its marketing efforts by further promoting hospital sales channels in European countries and building our pharmacy channels with a spillover effects from hospital to pharmacy. In June 2020, the Group’s enoxaparin finished doses obtained the approval for marketing in Switzerland, which marked as an important step for the Group in EU market. The access to the Swiss market is a recognition of our excellence in the quality of products, and further accelerate the Group to achieve full coverage of European market.

The sale of heparin API business, which accounted for 55.4% of the Group’s total sales revenue, amounted to approximately RMB 1,459.1 million, representing a year-on-year increase of 30%. The gross profit increased by 67.9% to RMB656.3 million, with a gross margin increased to 45% from 34.7% compared to the same period in 2019. The API business achieved outstanding growth and profit performance in the first half of 2020, which was primarily driven by the effectiveness of new pricing scheme formulated by the Group and its customers. This enabled the effective transmission of upstream cost fluctuations, and the gross profit level of the heparin API business improved significantly as compared to the same period of last year.

The CDMO business increased by 11% to RMB 386.8 million, and accounted for 14.7% of the Group’s total sales revenue. The gross profit increased by 49% to RMB123.2 million, with the gross margin increased by 8.1 percentage point to 31.9% compared to the same period in 2019. The simultaneous enhancement of the Group’s production capacity in the microbial fermentation and mammalian cell culture business lines, the further enhancement of its operational capabilities, as well as the successful cooperation with multinational companies and the maintenance of revenue growth contributed to the development of CDMO business. The gross profit margin of CDMO business was improved because of the increased utilization of scientific research and development.

Development of New Drugs is Progressing Steadily
During the Reporting Period, the Group anchored its efforts on research and development of innovative drugs. The Group made remarkable progress in the research and development of its two new drugs, Oregovomab and RVX-208. Oregovomab, the world’s first immunotherapy drug, can be used to treat advanced ovarian cancer; the PFS of the phase I clinical trial group is 41.8 months, which was nearly 3.5 times in compared to the control group (12.2 months). The Group is making strenuous preparations for the III phase of the clinical trial, and it is expected that Oregovomab will become the most effective first-line treatment for advanced ovarian cancer after the completion of the phase III. Besides, RVX-208, which is intended to reduce major adverse cardiovascular events among high-risk cardiovascular disease patients with type 2 diabetes mellitus, was granted Breakthrough Therapy Designation by the FDA in February 2020. Its phase III clinical protocol was reapproved by the FDA in June 2020, indicating that the new drug pipeline of the Group was recognized and supported by the regulatory authorities.

Mr. Li Li, the Chairman of the Board of Shenzhen Hepalink Pharmaceutical Co., Ltd. stated, “The outbreak of COVID-19 is expected to have a significant impact on every industry this year. We believe it is confronted with the opportunities and challenges. We achieved high growth from pharmaceutical products, development of innovative drugs and CDMO business, which were primarily driven by our long-term competitiveness. The COVID-19 pandemic poses significant risks to public health, many countries start to implement policies on reservation of medical resources and equipment, which is expected to drive the demand in the medium to long term. In light of these uncertainties, we will continue to closely monitor the market and utilize our advantage of global operating model in order to seize the market opportunities and strengthen cooperation with customers.” With regard to the plans for the second half of 2020, he added, “We will remain flexible and adjust our strategies from time to time to ensure that the Group can deliver steady growth. At the same time, the Group will continue to execute its strategies and plans to reach our annual targets and to achieve our goal of becoming a leading international pharmaceutical enterprise in the future.”

About Shenzhen Hepalink Pharmaceutical Co., Ltd.
Shenzhen Hepalink Pharmaceutical Co., Ltd. is a global pharmaceutical company with business spanning the manufacture and sale of pharmaceutical products, development of innovative drugs and CDMO services. The Company’s sales of pharmaceutical products consists of finished does pharmaceutical products which include enoxaparin sodium injection; active pharmaceutical ingredient (“API”) products including heparin sodium API and enoxaparin sodium API; and other products mainly including pancreatin API. The Company has obtained exclusive development and commercial rights in Greater China for clinical stage innovative drug candidates which are being developed for the treatment of disease with an immune system axis. The Company are also developing a self-discovered proprietary drug candidate currently at preclinical stage. The Company operate a CDMO business providing R&D, manufacturing, quality management and program management services, through the Company’s wholly-owned subsidiaries Cytovance Biologics, Inc. (the “Cytovance”), which specializes in the development and manufacture of recombinant pharmaceutical products and critical non-viral vectors and intermediates for gene therapy, and SPL Acquisition Corp. (the “SPL”), which provides services in the development and manufacture of naturally derived pharmaceutical products.


The Second “Chun Wo Innovation Student Awards” Receive Overwhelming Response – Attracts Over 70 Student Teams

A Microsoft Webinar is Organized to Explain Usage of AI Intelligent Technologies for Data Analysis

Microsoft Webinar – Digital Transformation for Smart City with Microsoft AI

Chun Wo Development Holdings Limited (“Chun Wo”), a key member of Asia Allied Infrastructure Holdings Limited (“Asia Allied Infrastructure” or “the Group”) (stock code: 00711.HK), is pleased to announce that the second “Chun Wo Innovation Student Awards” (the “Awards”) has received an overwhelmingly favorable response, attracting applications from over 70 student teams as of 30 April. This year’s theme “Engineers for a Smarter Future” aims to encourage full-time students of tertiary institutions in Hong Kong and the Greater Bay Area to solve problems relating to infrastructure, technology and social development in the city through engineering design.